DNA Methylation

The three mammalian 5-methylcytosine (5-mC) dioxygenases (Ten Eleven Translocation (TET); TET1, TET2, and TET3 in humans) convert 5-mC to 5-hydroxymethylcytosine (5-hmC) and subsequently to 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). This series of modifications is thought to represent one pathway to active DNA demethylation, thereby reshaping the methylated DNA landscape established by DNA methyltransferases (DNMTs). In addition, these marks, particularly 5-hmC, have been shown to be distinct epigenetic signatures in their own right impacting stem cell and cancer cell biology.

GeneTex introduces a selection of antibodies to targets relevant to DNA methylation and demethylation. We are proud to note that many of these antibodies are suitable for ChIP/ (h)MeDIP application.

TDG antibody GTX110473	DNMT1 antibody [N1], N-term GTX116011	TET2 antibody [N2-2], N-term GTX124205	DNMT3B antibody GTX129127

SIN3A antibody GTX129156	TET1 antibody [GT1462] GTX627420